Buy Nonapeptide-1 200mg (Topical) for Skin Brightening & Melanin Regulation
What is Nonapeptide-1 (Topical)?
Nonapeptide-1, also known as Melanostatine™-5, is a synthetic peptide sequence consisting of nine amino acids designed to inhibit melanin synthesis. It’s commonly studied in cosmetic and dermatological research for its potential in reducing hyperpigmentation, balancing skin tone, and preventing dark spot formation.
This peptide acts as a competitive antagonist of α-MSH (alpha-melanocyte-stimulating hormone), a key regulator in the production of melanin. Research suggests it may play a role in decreasing tyrosinase activity, helping to maintain brighter, more even skin pigmentation.
How Does Nonapeptide-1 Work?
Nonapeptide-1 functions by binding to the melanocortin-1 receptor (MC1-R) on melanocytes, blocking α-MSH signaling and inhibiting melanin biosynthesis.
Its action helps regulate melanogenesis, the process responsible for skin color, while maintaining natural cell health.
Mechanism of Action:
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Inhibits α-MSH–induced melanin synthesis
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Reduces tyrosinase enzyme activity
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Regulates pigment distribution in epidermal layers
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Supports studies on skin brightening, UV protection, and anti-aging applications
Key Research Benefits of Nonapeptide-1 200mg (Topical)
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May reduce hyperpigmentation and dark spots
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Helps achieve even skin tone in topical formulations
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Exhibits melanin-inhibiting properties through α-MSH suppression
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Supports studies on UV-related pigmentation and photoaging
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Demonstrates potential anti-inflammatory and soothing properties
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Commonly researched in combination with vitamin C, niacinamide, or other whitening peptides for synergistic effects
Product Details & Specifications
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Product Name: Nonapeptide-1 200mg (Topical)
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Category: Cosmetic Peptide / Research-Grade Topical
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Form: Lyophilized peptide powder
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Unit Size: 200mg per vial
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Purity: ≥99% (HPLC verified)
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Molecular Formula: C₄₅H₆₆N₁₂O₁₂
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Molecular Weight: 967.1 Da
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Solubility: Soluble in water, glycerol, or ethanol-based formulations
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Storage: Keep refrigerated at 2–8°C, away from light and moisture
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Shelf Life: 24 months (unopened vial)
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Intended Use: For topical research formulation only
Recommended Research Applications
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Cosmetic peptide formulation studies for skin tone regulation
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Melanin synthesis inhibition and depigmentation assays
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In-vitro testing of peptide-based anti-aging or brightening compounds
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Combination studies with skin barrier–supporting peptides or antioxidants
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Research on photoaging, UV damage, and oxidative stress reduction
Usage and Preparation
For research and formulation purposes, Nonapeptide-1 can be reconstituted in sterile distilled water, buffered saline, or cosmetic-grade solvents.
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Avoid high heat during dissolution
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pH range: 5.0 – 7.0 for optimal stability
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Store reconstituted solution at 2–8°C
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Protect from direct sunlight and oxidation
⚠️ For laboratory and formulation research only. Not approved for human or therapeutic use.
Safety, Handling & Storage
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Handle with protective equipment (gloves, mask, lab coat)
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Store sealed vials in cool, dry conditions (2–8°C)
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Do not freeze–thaw multiple times
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Dispose of according to local chemical safety standards
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Avoid contact with eyes or mucous membranes
Analytical Quality & Purity Testing
Each batch of Nonapeptide-1 undergoes comprehensive HPLC and mass spectrometry testing to confirm molecular identity and purity:
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Purity: ≥99%
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Appearance: White lyophilized powder
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GMP-manufactured and ISO 9001:2015 certified
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Certificate of Analysis (CoA) provided with every batch
This ensures reproducibility, accuracy, and consistency for laboratory research.
Why Choose Peptide Online Store for Nonapeptide-1 200mg?
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Guaranteed ≥99% peptide purity
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Research-grade quality for laboratory use
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Temperature-controlled global shipping
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Secure packaging for maximum peptide stability
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Transparent CoA verification on all orders
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Backed by GMP and ISO-certified manufacturing
At Peptide Online Store, we provide reliable cosmetic and research peptides that meet the highest analytical standards for precision and reproducibility.
Shipping & Delivery Information
All Nonapeptide-1 200mg (Topical) orders are:
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Dispatched within 24–48 hours
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Shipped worldwide with full tracking
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Temperature-stable packaging to maintain peptide integrity
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Include customs documentation for research-only clearance
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Delivered discreetly for privacy and safety
Related Products to Nonapeptide-1 (Topical)
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Palmitoyl Tripeptide-1 (Pal-GHK) 200mg – skin regeneration & elasticity support
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Palmitoyl Tetrapeptide-7 (Rigin) 200mg – soothing anti-inflammatory peptide
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Pal-AHK 200mg (Topical) – collagen synthesis & anti-aging research
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Copper Peptide GHK-Cu 200mg – antioxidant & wound-healing research
Frequently Asked Questions (FAQ)
Q1: What is Nonapeptide-1 primarily used for in research?
A: It’s studied for melanin regulation and skin-brightening effects by inhibiting α-MSH–induced pigmentation.
Q2: Is Nonapeptide-1 safe for human use?
A: No, this peptide is strictly for laboratory and formulation research only, not for personal or clinical application.
Q3: Can Nonapeptide-1 be combined with other peptides in formulations?
A: Yes, it’s often researched in combination with Pal-GHK, Niacinamide, and Vitamin C derivatives for enhanced brightening synergy.
Q4: How should I store Nonapeptide-1 after reconstitution?
A: Store at 2–8°C, protect from light, and use within the study period to maintain peptide stability.
Final Thoughts
Nonapeptide-1 200mg (Topical) is a scientifically backed depigmenting peptide known for its potential to reduce melanin synthesis and support even skin tone research. Its reliable molecular performance makes it a cornerstone ingredient in modern studies on cosmetic peptides, anti-aging, and skin brightening technologies.
At Peptide Online Store, every Nonapeptide-1 vial is analytically verified, GMP-produced, and carefully shipped to ensure your research integrity remains uncompromised.

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